Identification of Immunodominant Proteins of the Leishmania (Viannia) naiffi SubProteome as Pan-Specific Vaccine Targets against Leishmaniasis

Leishmaniasis is a wide-spectrum disease caused by parasites from Leishmania genus. A well-modulated immune response that established after the long-lasting clinical cure of leishmaniasis can represent standard requirement for vaccine. Previous studies demonstrated (Viannia) naiffi causes benign and its antigens induce responses in vitro. In this work we aimed to identify immunodominant proteins present soluble extract L. (sLnAg) as candidates composing pan-specific anti-leishmaniasis After immunoblotting using cured patients cutaneous sera proteomics approaches, identified group antigenic sLnAg. silico analyses allowed us select mildly similar host; addition, evaluated binding potential degree promiscuity protein epitopes HLA molecules B-cell receptors. We selected 24 sub-proteome with 328 proteins. Homology analysis identification 13 most orthologues among seven species. This these promising vaccine targets capable inducing humoral cellular humans, which may future contribute control leishmaniasis.